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Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease

A. E. EVANS, O. POIRIER, F. KEE, L. LECERF, E. MCCRUM, T. FALCONER, J. CRANE, D. F. O'ROURKE, F. CAMBIEN
DOI: http://dx.doi.org/ 211-214 First published online: 1 January 1994

Abstract

Summary It has been shown that myocardial infarction sur vivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme (ACE) gene than age-matched population controls. To test whether the association with coron ary risk had been under-estimated, the frequency of the ACE lID was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p<0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trend p=0.01). The findings bear out the hypothesis that the ACE l/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.