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Microscopic Polyarteritis: Presentation, Pathology and Prognosis

CAROLINE O. S. SAVAGE, C. G. WINEARLS, D. J. EVANS, A. J. REES, C. M. LOCKWOOD
DOI: http://dx.doi.org/ 467-483 First published online: 1 August 1985

Abstract

SUMMARY We have described 34 patients with microscopic polyarteritis, all of whom had clinical evidence of a systemic small vessel vasculitis predominantly affecting the skin and musculoskeletal systems accompanied by a focal necrotising glomerulonephritis with renal impairment. Thirty three patients received immunosuppressive treatment, comprising prednisolone, azathioprine, cyclophosphamide and plasma exchange in various combinations. The five-year actuarial patient and kidney survival rates were 65 and 55 per cent respectively, suggesting that aggressive immunosuppressive therapy in these patients is beneficial.