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QJM Advance Access published online on August 24, 2008
QJM, doi:10.1093/qjmed/hcn101
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© The Author 2008. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The impact of statin use on atrial fibrillation

J. Sánchez-Quiñones1, F. Marín2, V. Roldán3 and G.Y.H. Lip4

From the 1Department of Cardiology, Hospital General Universitario, Alicante, 2Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, 3Centro Regional de Hemodonación, University of Murcia, Spain and 4Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK

Address correspondence to Prof. G.Y.H. Lip, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK.


  Abstract

The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation (AF), inflammation and oxidative stress, with emphasis on the potential of statins to decrease the incidence of different types of AF, including new-onset AF, after electrical cardioversion (EC) and after cardiac surgery. Observational and clinical trials have studied the impact of statin therapy on new-onset, post-EC or postoperative AF. Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention. The data are insufficient to recommend the use of statins before EC. Finally, perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF.


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