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QJM Advance Access published online on March 8, 2007
QJM, doi:10.1093/qjmed/hcm007
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© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Human heart-type fatty-acid-binding protein as a point-of-care test in the early diagnosis of acute myocardial infarction

P. Mad1, H. Domanovits1, C. Fazelnia1, K. Stiassny1, G. Russmüller1, A. Cseh1, G. Sodeck1, T. Binder2, G. Christ2, T. Szekeres3, A. Laggner1 and H. Herkner1

From the Departments of 1Emergency Medicine, 2Cardiology, and 3Laboratory Medicine, Medical University Vienna, General Hospital, Vienna, Austria

Address correspondence to Dr H. Domanovits, Department of Emergency Medicine, Medical University Vienna, General Hospital, Waehringer Guertel 18–20, A-1090 Vienna, Austria. email: hans.domanovits{at}meduniwien.ac.at

Received 4 September 2006 and in revised form 14 November 2006


  Abstract

Background: At very early stages of acute myocardial infarction (AMI), highly sensitive biomarkers are still lacking.

Aim: To evaluate the utility of human heart-type fatty acid-binding protein (h-FABP) for early diagnosis of AMI.

Design: Prospective diagnostic study.

Methods: Consecutive patients presenting to the emergency department with chest pain or dyspnoea within 24 h of symptom onset were included. At presentation, the h-FABP test result was compared to the standard diagnostic work-up, including repeated ECG and troponin T measurements. Sensitivity analysis was performed for inconclusive tests.

Results: We enrolled 280 patients presenting to hospital with a median symptom onset of 3 h (IQR 2–6 h): 109 (39%) had AMI. At presentation, h-FABP had a sensitivity of 69% (95%CI 59–77) and specificity of 74% (95%CI 66–80); 45 tests were false-positive and 34 were false-negative. Omitting inconclusive tests increased sensitivity and specificity only slightly. AMI was identified significantly earlier by h-FABP than by troponin T (24 vs. 8 patients, p = 0.005).

Discussion: Although h-FABP can help to detect myocardial damage at an early stage in patients with chest pain or dyspnoea, it appears unsuitable as a stand-alone test for ruling out AMI.


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