Skip Navigation



QJM Advance Access published online on December 15, 2006
QJM, doi:10.1093/qjmed/hcl132
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
100/1/19    most recent
hcl132v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Seneviratne, S.L.
Right arrow Articles by Ogg, G.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seneviratne, S.L.
Right arrow Articles by Ogg, G.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The role of skin-homing T cells in extrinsic atopic dermatitis

S.L. Seneviratne1, A.P. Black1, L. Jones1, A.S. Bailey1 and G.S. Ogg1,2

From the 1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and 2Department of Dermatology, Churchill Hospital, Oxford, UK

Address correspondence to Dr S.L. Seneviratne, Cutaneous Immunology Group, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS. email: suran200{at}yahoo.co.uk

Received 12 May 2006 and in revised form 10 August 2006


  Abstract

Background: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease.

Aim: To investigate the immune phenotype and cytokine responses to Der p 1 stimulation of CLA+ T cells in extrinsic atopic dermatitis (EAD).

Design: In vitro testing, with controls.

Methods: Peripheral blood mononuclear cells (PBMC) were obtained from EAD patients (n = 27) and non-atopic healthy individuals (n = 22). Phenotypic analysis of naive, CLA+ and non-CLA+ memory/effector CD4+ and CD8+ T cells used markers of cell activation, differentiation, adhesion, apoptosis and chemokine receptor expression. Cytokine responses in these cells were studied following Der p 1 stimulation.

Results: CLA+ T cells from EAD patients expressed significantly higher levels of CD25, HLA-DR, CD38, CD71, CXCR1, CXCR2 and lower levels of bcl2, CCR5, CCR7, CXCR3, and CD62L (p < 0.05).

Discussion: In EAD patients, CLA+ T cells express increased levels of markers associated with activation, adhesion and apoptosis, show differences in the level of expression of differentiation markers and display a distinct chemokine receptor preference, compared with cells from healthy controls. These data suggest a significant role for CLA+ T cells in the pathogenesis of cutaneous atopic disease.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int ImmunolHome page
T. Kondo and M. Takiguchi
Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines
Int. Immunol., May 1, 2009; 21(5): 523 - 532.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.