QJM Advance Access published online on October 25, 2005
QJM, doi:10.1093/qjmed/hci135
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1 From the Essex Neuroscience Centre, Oldchurch Hospital, Romford, UK
* To whom correspondence should be addressed. Several factors appear to be associated with multiple sclerosis (MS), and each has a postulated immune or environmental explanation, but a common theme is lacking. This article suggests that a unifying premise could be risk-associated behaviour. Evidence is reviewed for associations with smoking, alcohol, recreational drug use, oral contraception, cholesterol intake, risk attitude and behaviour, ultraviolet light and vitamin D exposure, frequency of MS in healthy societies, and viral infection. The evidence associated with smoking, not taking vitamin D supplements and Epstein-Barr viral infection appears good. There may be a pattern of risk-associated behaviour that characterizes patients with MS and brings them into contact with one or more causative agents. Of the possible agents, viral infection seems the most likely.
Commentary
Are multiple sclerosis patients risk-takers?
C.H. Hawkes, E-mail: chrishawkes{at}msn.com
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C.H. Hawkes Smoking is a risk factor for multiple sclerosis: a metanalysis Multiple Sclerosis, June 1, 2007; 13(5): 610 - 615. [Abstract] [PDF] |
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