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QJM 2006 99(8):555-559; doi:10.1093/qjmed/hcl056
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© The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Commentary

C-reactive protein and colorectal cancer

D. Mazhar and S. Ngan

From the Department of Oncology, Medical Day Unit, Chelsea and Westminster Hospital, London, UK

Address correspondence to Dr D. Mazhar, Department of Oncology, Medical Day Unit, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH. email: d.mazhar@imperial.ac.uk

The first 150 words of the full text of this article appear below.


   Introduction
 
There is no doubt that colorectal cancer poses a significant clinical burden. According to Cancer Research UK, there are around 35 000 new cases of large-bowel cancer in the UK annually, making it the second most common malignancy in women, and the third most common in men. In 2002, there were 16 220 deaths from the disease.1 Overall, around 40% of sufferers survive for 5 years. Early diagnosis leads to improved outcomes, and in October 2004 the government announced that a National Screening Programme using faecal occult blood testing will be introduced in April 2006.

There has been interest in identifying factors that could help predict colorectal cancer risk. Chronic inflammation has been linked to several solid malignancies, including cancers of the oesophagus, stomach, liver, pancreas, kidney and prostate. Possible mechanisms by which inflammation may contribute to carcinogenesis include: (i) the elaboration of cytokines and growth factors that favour tumour . . . [Full Text of this Article]


   C-reactive protein
 

   Prospective studies
 

   Conclusions
 

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