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QJM Advance Access originally published online on March 7, 2006
QJM 2006 99(7):469-473; doi:10.1093/qjmed/hcl035
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© The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Commentary

Dietary fat and breast cancer

D. Mazhar and J. Waxman

From the Department of Cancer Medicine, Imperial College London, London, UK

Address correspondence to Professor J. Waxman, Department of Cancer Medicine, Division of Medicine, Faculty of Medicine, Imperial College London, Room 1014 Garry Weston Centre, Hammersmith Campus, Du Cane Road, London W12 0NN. email: j.waxman@imperial.ac.uk

The first 150 words of the full text of this article appear below.


    Introduction
 
Breast cancer is the most frequently diagnosed malignancy, and the second commonest cause of cancer deaths amongst women in industrialized countries. Incidence rates have been increasing for decades. Breast cancer currently afflicts almost 40 000 women in the UK each year, with the lifetime risk for each woman in the UK estimated at 1:9.1 High penetrance susceptibility genes such as BRCA1 and BRCA2 account for only 5% of breast cancer cases; the factors responsible for the other 95% remain largely obscure. Age, family history, and various menstrual and reproductive factors are known to influence an individual's risk of developing breast cancer, but we are currently unable to ascribe a cause for the vast majority of cases of breast cancer. There are pointers to environmental factors: populations that migrate from low- to high-incidence countries often develop breast cancer rates that approximate those of the host country.2,3 One environmental factor that may . . . [Full Text of this Article]


    Pre-clinical studies
 

    Epidemiological studies
 
Body mass index and risk
Retrospective studies
Prospective studies

    Dietary fat and survival from breast cancer
 

    Dietary fat and risk of breast cancer relapse
 

    Diet and oestrogen levels
 

    Adolescent diet and breast cancer risk
 

    Conclusion
 

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