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QJM Advance Access originally published online on November 10, 2005
QJM 2005 98(12):885-893; doi:10.1093/qjmed/hci139
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© The Author 2005. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Patient perspectives on multiple medications versus combined pills: a qualitative study

B. Williams, A. Shaw1, R. Durrant, I. Crinson1, C. Pagliari2 and S. de Lusignan1

From the Division of Community Health Sciences, University of Dundee, Dundee, 1Department of Community Health Sciences, St George's Hospital Medical School, London, and 2School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, UK

Address correspondence to Dr B. Williams, Division of Community Health Sciences, Mackenzie Building, Kirsty Semple Way, University of Dundee, Dundee DD2 4BF. email: b.y.williams{at}chs.dundee.ac.uk

Received 9 August 2005 and in revised form 25 September 2005

Background: A growing number of patients are taking multiple medications. Unfortunately, adherence may fall as drug numbers and procedural complexity increase. While there are plausible theoretical reasons why combining pills might improve non-adherence, patients’ attitudes are unknown.

Aim: To explore attitudes and practices to medication regimens among patients already in receipt of multiple medications, and to assess whether a combined tablet would be perceived as advantageous.

Design: Qualitative study.

Methods: Ninety-two men and women aged >40 years currently receiving both antihypertensive and cholesterol-lowering medications took part in 14 focus groups.

Results: Drugs were seen as unwelcome but necessary. Some took drugs flexibly by changing dose timing, thereby increasing the complexity of their regimen. A routine was seen as the key to coping with multiple medications, although it was sometimes threatened by changes in prescriptions and life circumstances. While some participants welcomed a combined pill, there was uncertainty about whether a combination that mirrored their current doses would be available. There were also concerns about tablet size, allergies, the attribution of side-effects, timing of tablets throughout the day, and the ability to alter dose levels.

Conclusions: While some patients would be willing to try a combined pill and would appreciate the associated convenience, they are likely to have a number of concerns that prescribers should address. Willingness to move to combined therapy may be hindered if drug combinations that mirror personalized and trusted regimens are not available.


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