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Q J Med 2004; 97: 551-552
QJM vol. 97 no. 8 © Association of Physicians 2004; all rights reserved.

Biologic

Patterns of thought

Colin Berry

The first 10% of the full text of this article appears below.

The cerebral cortex of mammals is largely responsible for their complex behavioural repertoire, and is a comparatively new structure in phylogenetic terms. The late expansion of the neocortex has resulted in an organ that is highly structured in two orthogonal planes. Parallel to the pial surface are six layers, each of which contains neurons with similar morphology and projection patterns. The formation of this pattern is now well understood: post-mitotic neurons migrate away from a proliferating peri-ventricular zone and form distinct layers (laminae) in the developing cortical plate. The cortical layers are generated in an inside-out pattern; neurons of the deep layers 6 and 5 arrive first in the cortical plate, and are followed by cells of . . . [Full Text of this Article]


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