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QJM 2004 97(12):809-816; doi:10.1093/qjmed/hch130
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QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease

A.G. Rumley1, M. Woodward2, A. Rumley3, J. Rumley3 and G.D.O. Lowe3

From the 1Institute of Clinical Biochemistry, Royal Infirmary, Glasgow, UK, 2 Institute for International Health, University of Sydney, Australia, and 3 University Department of Medicine, Royal Infirmary, Glasgow, UK

Received 14 July 2003 and in revised form 26 August 2004

Background: The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined.

Aim: To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample.

Design: Random, age- and sex-stratified population sample.

Methods: We studied 739 men and women aged 25–74 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples.

Results: Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r = 0.33; p < 0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men.

Discussion: These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.

Address correspondence to Professor G.D.O. Lowe, University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER. e-mail: gdl1j{at}clinmed.gla.ac.uk


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