Q J Med 2003; 96: 91-102
© 2003 Association of Physicians
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Clinical advances in therapies targeting the interleukin-2 receptor
From the Department of Respiratory Medicine, Glasgow Royal Infirmary, Glasgow, UK
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Introduction |
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A dominant theme in modern immunological research is the elucidation of how the different branches of the immune system communicate. Identification of receptors for antigens, co-receptors such as CD4 and CD8, major histocompatibility complex (MHC) molecules and cytokine receptors, has gone a long way to giving a clearer view of the complexities of this interaction. More recently, this new information has opened up avenues for therapeutic intervention by directing novel treatments towards these various receptors. This new strategy of immune-receptor-directed therapy has been applied to an array of human disorders both in the laboratory and clinical settings.
Perhaps one of the most important, and certainly most studied, cytokines is interleukin-2 (IL-2). This molecule was first identified in 1976 by Morgan as a substance present in the supernatant of activated peripheral blood lymphocytes that was capable of driving the growth and proliferation of lymphocytes in vivo.1 Recent molecular biological advances
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Methods |
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Molecular biology of IL-2 and its receptor |
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The development of the IL-2 receptor as a target |
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The development of IL-2 receptor antibodies |
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Clinical application of anti-IL2 receptor antibody |
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Neoplasia
Autoimmunity
Transplantation
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Functional implications of blocking IL-2 mediated signalling |
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Future developments |
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