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Q J Med 2002; 95: 557-558
© 2002 Association of Physicians

Editorial

Faecal calprotectin: a bright future for assessing disease activity in Crohn's disease

D.R. Gaya and J.F. Mackenzie

Glasgow Royal Infirmary, Glasgow e-mail: danielgaya@aol.com

The first 10% of the full text of this article appears below.

Calprotectin is a calcium-binding protein with in vitro bacteriostatic and fungistatic properties. It is found in abundance in neutrophils, where it accounts for 60% of the protein in the cytosol; lower concentrations are found in monocytes and reactive macrophages. It was hoped that measurement of faecal calprotectin would represent a surrogate marker of neutrophil influx into the bowel lumen and in turn act as a marker of intestinal inflammation. Studies to date support this hypothesis; increased levels of faecal calprotectin are found in inflammatory bowel disease,1,2 colonic cancer3 and non-steroidal anti-inflammatory drug (NSAID) . . . [Full Text of this Article]


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