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Q J Med 2002; 95: 339-341
© 2002 Association of Physicians

Editorial

Reducing cholesterol and atherosclerosis

R.S. Hornung

University Hospital Aintree, Liverpool

The oxidative modification of low-density lipoprotein (LDL) is an important pre-requisite for macrophage uptake and accumulation of cellular cholesterol ester in the arterial wall. This is a key component to the development of the atherosclerotic lesion.

Patients with coronary artery disease (CHD), i.e. stable and unstable angina and acute myocardial infarction, have significantly elevated levels of oxidized LDL when compared with age-matched controls; however, at any given concentration of plasma cholesterol, there is considerable variability in the clinical expression of CHD. This reflects the diversity in the reaction of the arterial wall to hypercholesterolaemia and the associated changes in endothelial function, immunological effects, smooth muscle cell proliferation and coagulation. Despite the complexity of these responses, opinion is generally united that LDL-cholesterol lowering is . . . [Full Text of this Article]

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