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Q J Med 2002; 95: 691-693
© 2002 Association of Physicians

Commentary

Uric acid: an important antioxidant in acute ischaemic stroke

W.S. WARING

From the Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK

The first 10% of the full text of this article appears below.


   Introduction
 
An association between raised serum uric acid (UA) concentration and increased cardiovascular risk has been recognized for over 50 years.1 A number of major epidemiological studies have identified high UA concentrations as an important risk marker for stroke in unselected populations. Furthermore, raised serum UA concentrations are associated with increased risk of stroke in high risk patient groups, for example those with hypertension or type 2 diabetes mellitus.2,3 However, the significance of these relationships remains subject to considerable debate. Both in vitro and in vivo studies have shown UA to be a powerful free radical scavenger in humans and, paradoxically, these antioxidant properties could be expected to offer a number of benefits within the cardiovascular system.4 No potential biological mechanisms are known by which raised UA . . . [Full Text of this Article]


   Antioxidants and stroke
 

   Uric acid
 

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