Q J Med 2001; 94: 121-125
© 2001 Association of Physicians
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Growth failure and intestinal inflammation
From the Digestive Diseases Research Centre, and 1 Department of Paediatric Endocrinology 2 Department of Paediatric Gastroenterology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK
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Introduction |
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At least one third of patients with inflammatory bowel disease (IBD), namely Crohn's disease and ulcerative disease (UC), first develop symptoms during childhood and adolescence. In contrast to the adult population, in which the incidence of Crohn's disease has plateaued, the incidence of juvenile-onset Crohn's disease continues to increase.1 The clinical spectrum and severity of disease varies considerably in young people, as it does in adults, but there are a number of special problems that face children and adolescents with IBD. In this review we will discuss the prevalence, aetiology, pathogenesis and management of growth failure in these patients.
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Prevalence and natural history of growth failure |
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Growth failure frequently complicates the clinical course of children with IBD, more often in Crohn's disease than in UC.2,3 Its reported frequency depends to some extent on its definition; a reduction in height velocity is the most accurate measurement of growth. A decrease in height velocity below the third centile has
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Aetiology and pathogenesis of growth failure |
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Endocrine mediators of growth failure |
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Cytokines and growth failure |
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Management of growth failure |
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Acknowledgments |
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Notes |
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References |
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