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Q J Med 2001; 94: 69-77
© 2001 Association of Physicians

Renal complications of jejuno-ileal bypass for obesity

D.R. Mole, C.R.V. Tomson1, N. Mortensen2 and C.G. Winearls

From the Oxford Kidney Unit, The Churchill, Oxford Radcliffe Hospitals, Oxford, 1 The Richard Bright Renal Unit, Southmead Hospital, Westbury-on-Trym, Bristol, and 2 Colorectal Surgery Unit, The John Radcliffe, Oxford Radcliffe Hospitals, Oxford, UK

Received 23 June 2000 and in revised form 9 November 2000

Jejuno-ileal bypass has until recently been an accepted treatment for refractory morbid obesity. Although hyperoxaluria causing renal tract calculi is a well-recognized complication, we describe eight patients who developed significant renal failure attributable to hyperoxaluria resulting from this procedure, three requiring renal replacement therapy. We review the literature, describing 18 other cases with renal failure, the mechanisms of hyperoxaluria and its treatment. Because reversal of the bypass may result in stabilization or partial improvement of renal function, these patients require long-term follow-up of renal function.

Address correspondence to Dr C.G. Winearls, Oxford Kidney Unit, The Churchill, Oxford Radcliffe Hospitals, Headington, Oxford OX3 7LJ. e-mail: Christopher Winearls{at}orh.nhs.us


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