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Q J Med 2000; 93: 563-565
© 2000 Association of Physicians

Editorial

Atrial electrical remodelling and atrial fibrillation

C.J. Garratt and S.P. Fynn

Manchester Heart Centre, Manchester Royal Infirmary, Manchester

Atrial fibrillation (AF) is the most common tachyarrhythmia in humans. It causes palpitations, decreased cardiac output, heart failure and systemic thromboembolism, and is associated with significant morbidity, mortality1 and healthcare costs. Current treatment strategies for AF are far from satisfactory.

Atrial fibrillation has a tendency to become more persistent with time, a large percentage of patients with paroxysmal AF eventually developing chronic AF.2 Although progression of an underlying disease has previously been considered as the most likely explanation for this phenomenon, in a proportion of cases, no underlying disease is evident. Recently Wijffels and coworkers have demonstrated, in a chronically instrumented conscious goat model, that episodes of AF may be self-perpetuating (‘AF begets AF’) and have suggested that there may . . . [Full Text of this Article]

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