Q J Med 2000; 93: 261-267
© 2000 Association of Physicians
Pulmonary embolism—an update on thrombolytic therapy
M.D. Thomas,
A. Chauhan1 and
R.S. More
From the Department of Cardiology, St Mary's Hospital, Portsmouth, and
1 Department of Cardiology, Victoria Hospital, Blackpool, UK
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Introduction
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Pulmonary embolism is a commonly encountered disorder, usually
precipitated by deep venous thrombosis, and is associated with
significant morbidity and mortality. It accounts for 10% of
all deaths in hospital, and is a major contributing factor in
a further 10%.
1 It can result in pulmonary hypertension and
right ventricular dysfunction, and its mortality rate of approximately
14%,
2 has changed little over the last 30 years.
1We review the
treatment of pulmonary embolism, with particular reference to
thrombolytic therapy. The role of surgical or catheter-based
embolectomy will not be discussed.
The initial diagnosis of pulmonary embolus is not always straightforward. In one report, pulmonary embolus was not clinically suspected in 70% of patients in whom it was subsequently considered to be the major cause of death.3 Conversely, another autopsy series found that 63% of patients thought to have had a pulmonary embolus had no such evidence.4 The ‘classical’ presentation is pleuritic . . . [Full Text of this Article]
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Predisposing factors
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Consequences of pulmonary embolism
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Treatment
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Comparison of thrombolysis and anticoagulation
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tPA efficacy
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Comparison of different thrombolytic agents
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Bolus regimens
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Locally delivered thrombolytic therapy
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Conclusions
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Notes
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References
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CiteULike 
Connotea 
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O.M.P. Jolobe
Pulmonary embolism--an update on thrombolytic therapy
QJM,
August 1, 2000;
93(8):
557 - 557.
[Full Text]
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