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Q J Med 1999; 92: 283-286
© 1999 Association of Physicians

Psychiatric morbidity in patients with systemic lupus erythematosus

K.N. Purandare, A.C. Wagle1 and S.R. Parker2

From the Department of Psychiatry, Fairfield Hospital, Hutchen, 1 General Adult Psychiatry, Addenbrooke's and Fulbourn Hospital, Cambridge, UK, and 2 King Edward VII Memorial Hospital, Mumbai, India

Received 28 January 1999 and in revised form 12 March 1999

Dr A.C. Wagle, Drug, Alcohol and Tranquilizer Services, The Mill House, 351 Mill Road, Cambridge CB1 3DF. e-mail: ajaywagle{at}msn.com

We investigated psychiatric morbidity in patients with systemic lupus erythematosus, in a hospital-based study. Thirty patients (23 consecutive out-patients and seven unselected in-patients) were prospectively assessed by a multidisciplinary team for the presence of psychiatric disorders and disease activity. Psychiatric assessment was done with structured interviews. Demographic information was recorded in a structured proforma; all the patients completed the Presumptive Stressful Life Event Scale. A close relative was interviewed in every case. Patients who had psychiatric disorders were compared with the rest with respect to demographic variables, lupus disease activity, use of steroids, and stressful life events. We found a 50% prevalence of psychiatric disorders. The patients with psychiatric disorders were similar to those who had no psychopathology with respect to age, sex, duration of illness, lupus activity and the use of steroids. However, they had experienced more stressful life events in the last year.


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J Segui, M Ramos-Casals, M Garcia-Carrasco, T de Flores, R Cervera, M Valdees, J Font, and M Ingelmo
Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease
Lupus, October 1, 2000; 9(8): 584 - 588.
[Abstract] [PDF]


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