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Q J Med 1999; 92: 239-244
© 1999 Association of Physicians

Mini-review

Antioxidant therapy for the prevention of cardiovascular disease

S.L. Nuttall, M.J. Kendall and U. Martin

From the Clinical Pharmacology Section, Department of Medicine, University of Birmingham, Birmingham, UK

S.L. Nuttall, Department of Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TH

Introduction

Coronary artery disease (CAD) is the major cause of death in developed countries.1 It may present as a typical `heart attack', as sudden death, or it may be detected at a later date and be described as a silent infarct. Good coronary care units, the use of thrombolytic and anti-arrhythmic drugs, and accurate methods for assessing cardiac function and coronary artery pathology have all successfully reduced in-hospital mortality. However, about 75% of those who have a myocardial infarction (MI) die outside hospital,2 and sudden death is the first and only manifestation in about 20% of all those who present with CAD.3,4 Therefore, treatment is not available for most patients, and the aim must be to prevent the development and progression of CAD.

There are five conditions that predispose to premature death from CAD. These are: hypertension;5,6 hypercholesterolaemia;7,8 the post-menopausal state;9,10 a thrombotic tendency;11,12 and the risk of developing ventricular arrhythmias.13 . . . [Full Text of this Article]

Free radicals and antioxidants

Oxidative damage
Oxidative damage in cardiovascular disease
Antioxidants
A protective role for antioxidants in CAD

Antioxidant activity of red wine

Antioxidant activity of a pharmaceutical preparation: a preliminary study

Conclusions

References


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