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Q J Med 1999; 92: 609-617
© 1999 Association of Physicians

Commentary papers

Study requirements for investigating HLA-associated progression of HIV disease, and review

S.M. Gore, S.J. Hutchinson1 and R.P. Brettle2

From the MRC Biostatistics Unit, Cambridge, and 1 MRC-BIAS and 2 Regional Infectious Diseases Unit, Edinburgh, UK

Dr S.M. Gore, MRC Biostatistics Unit, Robinson Way, Cambridge CB2 2SR

Introduction

Human Leukocyte Antigens (HLA), also known as transplantation antigens, determine the immune response. We give a brief account of them, and of more complex immunology, to explain why HLA phenotype may be specifically important in HIV disease, as it is in other infectious diseases.1 Study requirements for investigating HLA-associated progression of HIV disease are illustrated with Scottish data; susceptibility to HIV infection is considered only briefly.

Systematic review of published and other diverse data on three HLA associations with HIV progression is attempted, and the difficulties illustrated, for: the ancestral phenotype HLA-A1, B8, DR3 (which is associated with a range of autoimmune diseases); the allele B35 (which is common in Africans, and has been implicated empirically in HIV progression); and B27 (because Ohno2 established a theoretical basis for its association with slow HIV progression, which McNeil et al.3 corroborated).

The systematic review suggests that major HLA effects on HIV progression . . . [Full Text of this Article]

Human leukocyte antigens (HLA)

Complex immunology: influence of HLA on HIV disease progression?

Study requirements and biostatistical notes

Susceptibility
Progression
Interval 1
Interval 2
Interval 3
Interval 4
Results

Systematic review essayed: HLA-A1, B8, DR3; B35; B27
Other data sources
Discussion

Acknowledgments

References


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