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Q J Med 1999; 92: 579-585
© 1999 Association of Physicians

Antioxidant enzymes, inflammatory indices and lifestyle factors in older men: a cohort analysis

C.W. Mulholland, P.C. Elwood1, A. Davis1, D.I. Thurnham, O. Kennedy, J. Coulter, A. Fehily2 and J.J. Strain

From the Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Northern Ireland, 1 Centre for Applied Public Health Medicine, University of Wales College of Medicine, Cardiff, and 2 Heinz Ltd, UK

Received 5 February 1999 and in revised form 6 August 1999

Dr C.W. Mulholland, Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, County Londonderry, Northern Ireland

We examined the relationship between blood antioxidant enzyme activities, indices of inflammatory status and a number of lifestyle factors in the Caerphilly prospective cohort study of ischaemic heart disease. The study began in 1979 and is based on a representative male population sample. Initially 2512 men were seen in phase I, and followed-up every 5 years in phases II and III; they have recently been seen in phase IV. Data on social class, smoking habit, alcohol consumption were obtained by questionnaire, and body mass index was measured. Antioxidant enzyme activities and indices of inflammatory status were estimated by standard techniques. Significant associations were observed for: age with {alpha}-1-antichymotrypsin (p<0.0001) and with caeruloplasmin, both protein and oxidase (p<0.0001); smoking habit with {alpha}-1-antichymotrypsin (p<0.0001), with caeruloplasmin, both protein and oxidase (p<0.0001) and with glutathione peroxidose (GPX) (p<0.0001); social class with {alpha}-1-antichymotrypsin (p<0.0001), with caeruloplasmin both protein (p<0.001) and oxidase (p<0.01) and with GPX (p<0.0001); body mass index with {alpha}-1-antichymotrypsin (p<0.0001) and with caeruloplasmin protein (p<0.001). There was no significant association between alcohol consumption and any of the blood enzymes measured. Factor analysis produced a three-factor model (explaining 65.9% of the variation in the data set) which appeared to indicate close inter-relationships among antioxidants.


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