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Q J Med 1999; 92: 5-10
© 1999 Association of Physicians

Mini-reviews

Genetic predisposition to gastric cancer

S. Bevan and R.S. Houlston

From the Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK

Introduction

Wide variations exist in the incidence of gastric cancer between populations. In Japan, the incidence is as high as 80 per 100 000 males, whilst in most African states the overall incidence is only 5 per 100 000. In Europe, incidence rates are between 20 and 40 per 100 000, and females have about half the male gastric cancer risk.1

Approximately 90% of gastric cancers are adenocarcinomas. These can be classified according to their differentiation or according to the histomorphological classification of Lauren, which divides the tumours into `intestinal' and `diffuse'.2 Intestinal tumours are usually exophytic, often ulcerating, and are associated with intestinal metaplasia of the stomach. Diffuse tumours are poorly differentiated infiltrating lesions which lead to thickening of the stomach (linitis plastica). Patients with diffuse-type tumours have a worse prognosis than those with an intestinal type. Intestinal cancers appear to be more common in proximal (fundus) localized . . . [Full Text of this Article]

Evidence for a genetic predisposition to gastric cancer

Predisposition syndromes

Predisposition genes

Conclusions

Notes

References


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