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Q J Med 1994; 87: 311-314
© 1994 Association of Physicians

research-article

Inhibition of phagocytes by cyclosporin in vitro

S.P. THORAT, U.M. THATTE, N. PAI and S.A. DAHANUKAR

Department of Pharmacology, Seth G.S. Medical College and K.E.M. Hospital Parel, Bombay, India

Address correspondence to Dr Sadhna Thorat, A/8 Ramdarshan, Subhash Road, Vileparle (E), Bombay 400 057, India

Received 25 February 1994 Accepted for publication 14 March 1994.

Cyclosporin is an immunosuppressant that acts by selectively inhibiting the activation of T lymphocytes. Its effects on monocytes and neutrophils are not well explored. We investigated the in vitro effects of cyclosporin on these cells, harvested from venous blood from nine healthy, non-smoking volunteers. In vitro incubation of monocytes with increasing concentrations of cyclosporin (5, 25 and 625 µg) depressed their phagocytosis by 22%, 32% and 49%, respectively, compared to the control values. The intracellular killing capacity of monocytes

decreased by 26%, 31 % and 43% with these doses, and neutrophil phagocytosis was depressed in a similar manner (16%, 30% and 40%). Patients receiving cyclosporin are susceptible to infections, and inhibition of these phagocytic cells by cyclosporin may be partly responsible for this. Neutrophil chemotaxis is reduced in patients with impaired renal function. Treating these patients with cyclosporin may in addition suppress the phagocytic function of these cells.


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