Q J Med 1994; 87: 671-678
© 1994 Association of Physicians
research-article |
Birmingham Vasculitis Activity Score (BVAS) Dim system necrotizinig vasculitis
From the Departments of Rheumatology Edgbaston, West Midlands, UK 1From the Nephrology, University of Birmingham Edgbaston, West Midlands, UK
Address correspondence to Professor P.A. Bacon, Department of Rheumatology, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT
Received 25 March 1994 Accepted for publication 4 May 1994.
The continuing morbidity of patients with vasculitis despite the improved prognosis with aggressive therapy, underlines the need for accurate disease assessment We have devised a clinical index of disease activity, and evaluated its use in several forms of necrotizing vasculitis. The weighted score is based on symptoms and signs in nine separate organ systems. Disease features are only scored if they are attributable to active vasculitis. The Birmingham Vasculitis Activity Score (BVAS) was compared with two other published vasculitis activity scores, with the physician's global assessment (PGA), with outcome, and with serological markers of disease activity. In a cross-sectional study of 213 consecutive patients with different forms of vasculitis, all 107 vasculitis patients who were judged completely well on clinical assessment had a BVAS score of 0. Twenty-two patients with active vasculitis prior to treatment had a median score of 7.5 (range 4–30) and 69 with active disease on treatment had a median score of 10 (1–29). Of the 12 who died, median score immediately prior to death was 20.5 (9–30). In a serial prospective study, 30 cases had documented episodes of active disease. During periods of disease activity, the median BVAS values were significantly higher than in remission (15 [range 3–32] vs. 0 [0–2], p < 0.001); the same was true for CRP values (80 [9–361] vs. 13.5 [5–68], p < 0.001). This was not true for erythrocyte sedimentation rate (ESR), haemoglobin (Hb) or von Willebrand factor (VWF). In three patients with clinically active disease requiring change of therapy, BVAS was elevated whereas the CRP remained < 20; in nine patients in clinical remission, BVAS was < 2 whilst CRP remained > 20. BVAS had low inter-observer variability, and agreed significantly with two other indices of disease activity. This clinical activity index allows precise assessment of organ involvement in vasculitis compared to a global assessment, whilst the cumulative index provides a useful standard by which to assess serological markers and the need for further therapy.
* Present address: Dr R.A. Luqmani, Regional and Academic Rheumatology Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU
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