Q J Med 1990; 75: 365-370
© 1990 Association of Physicians
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Fulminant Fungal Sinusitis Following Intensive Chemotherapy
Department of Haematological Medicine, King's College School of Medicine and Dentistry London *Department of Medical Microbiology, King's College School of Medicine and Dentistry London **Department of Morbid Anatomy, King's College School of Medicine and Dentistry London
Address Correspondence to Dr. G. Mufti.
Accepted for publication 17 October 1989.
Three cases of fulminant fungal sinusitis in patients undergoing intensive chemotherapy for haematological malignancies are described. Predisposing factors included courses of broad-spectrum antibiotics for febrile episodes. The presentation of sinusitis was acute, with facial pain and swelling, progresing to proptosis and visual disturbance. CT scanning is the investigation of choice to assess the extent of disease and subsequent response to treatment. Management requires urgent drainage, systemic and local antifungal therapy and decompressive procedures in necessary. Aggressive management can achieve good local control, but the long-term outlook remains poor.