© 2007 The Author(s)
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IgG4-associated multifocal systemic fibrosis presenting with fever of unknown origin
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Sir,
Autoimmune pancreatitis is characterized by significant lymphoplasmacytic infiltration and fibrosis of the pancreas,1 with high serum IgG4 concentrations and/or IgG4-positive plasma cell infiltration.2,3 The disease may be complicated by a variety of extra-pancreatic lesions,2,3 suggesting the possibility of systemic disease, recently described as IgG4-associated multifocal systemic fibrosis.4
Of 31 patients admitted to our hospital with a fever
First Department of Internal Medicine
Center for Health, Safety and Environmental Management
Second Department of Internal Medicine
Shinshu University School of Medicine
Matsumoto City
Japan
email: tsushima@hsp.md.shinshu-u.ac.jp