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QJM Advance Access originally published online on May 12, 2008
QJM 2008 101(7):591; doi:10.1093/qjmed/hcn063
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© The Author 2008. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The hidden anti-phospholipid antibody syndrome

Sir,

Kalita and colleagues report three interesting cases of women with cerebral venous sinus thrombosis leading to intracerebral haemorrhage.1 However, they cited that the underlying conditions could not be identified, I disagree. The authors performed prothrombotic screenings but failed to include anti-phospholipid antibody syndrome (APS) among other differentials. These are common disorders, which might be the hidden causes in the patients2 And cerebral venous sinus thrombosis is a well known complication of such disorder.3,4 I believe that anti-cardiolipin antibodies and lupus anticoagulant must be screened in the authors’ patients.

Last but not least, ‘APS must be detected for any unknown hypercoagulable states’.

W. Kittisupamongkol

Surin Hospital
Surin 32000
Thailand

email: weekitti{at}gmail.com

References

1. Kalita J, Bansal V, Misra UK, Jain SK. Intracerebral haemorrhage due to cerebral venous sinus thrombosis. Q J Med (2008) 101:247–9.[Web of Science]

2. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med (2002) 346:752–63.[Free Full Text]

3. Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med (2005) 352:1791–8.[Free Full Text]

4. Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurol (2007) 6:162–70.[CrossRef][Web of Science][Medline]


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This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
101/7/591    most recent
hcn063v1
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