The Association of Physicians of Great Britain and Ireland 2007
One Hundred and First Annual General Meeting
The One Hundred and First Annual General Meeting was held in the Chemistry Lecture Theatre on the Main Campus of the University of Bristol, on 29 and 30 March 2007. The attendance book was signed by Ordinary Members and Senior Members.The President, Professor Edwin Gale, took the chair.
The Minutes of the last Annual General Meeting, having been published in the QJM, were taken as read, confirmed and signed. The following Officers and Executive Officers were elected:
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Executive Committee |
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 Top Executive Committee Ordinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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Members for England and Wales
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Members for Scotland
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Members for Ireland
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Honorary Members
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Senior Members
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Ordinary Members |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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There were 23 nominated from 35 proposals received.
Aitman, Timothy, BSc, MB ChB, MSc, D.Phil, FRCP, FMedSci. Group Head and Section Chair, Physiological Genomics & Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN.
Burden, David, BSc, MBChB, MD, MRCP, DTM&H. Consultant Dermatologist and Hon. Clinical Senior Lecturer, Alan Lyell Dermatology Centre, Western Infirmary, Glasgow G11 0NT.
Burn, David, BSc, MBBS, MA, MD, FRCP. Professor in Movement Disorders, Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne NE4 6BE.
Condliffe, Alison, BA, MBBS, MRCP, PhD. Senior Research Associate, Hon. Consultant Physician, Department of Medicine, University of Cambridge School of Clinical Medicine, Box 157, Addenbrooke's Hospital, Hill's Road, Cambridge CB2 2QQ.
Davies, Robert, BM, DM, FRCP. Reader and Consultant in Respiratory Medicine, Oxford Centre for Respiratory Medicine & University of Oxford, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ.
Djukanovic, Ratko, MD. Professor of Respiratory Medicine, Mailpoint 810, Level F, South Block, Southampton General Hospital, Southampton SO16 6YD.
Dorling, Anthony, MBBS, PhD, FRCP. Reader and Hon. Consultant in Medicine, Department of Immunology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN.
Ferro, Albert, BSc, MBBS, MRCP, PhD. Senior Lecturer and Hon. Consultant Physician, 238A New Hunts House, King's College London, Guy's Hospital Campus, London Bridge, London SE1 1UL.
Forbes, Stuart, MB ChB, MRCP, PhD. Professor of Transplantation and Regenerative Medicine, Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ.
Godkin, Andrew, BA, MA, MBBChir, MRCP, MD. Consultant in Gastroenterology and Hon. Senior Lecturer, Department of Gastroenterology and Hepatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XX.
Grace, Andrew, MB BS, PhD, FRCP. Consultant Cardiologist and Senior Research Fellow, Department of Cardiology, Papworth Hospital, Cambridge CB3 8RE.
Leyton, Mark, MBBS, FRCP, MRCPCH, FRCPCH. Consultant and Hon. Reader, Department of Haematology, Faculty of Medicine, Imperial College, 4th Floor, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN.
Malik, Rayaz, BSc, MSc, MBChB, MRCP, PhD. Senior Lecturer and Consultant Physician, Room 3.15A, Cardiovascular Research Group, Division of Cardiovascular and Endocrine Sciences, Core Technology Facility (3rd Floor), University of Manchester, 46 Grafton Street, Manchester M13 9NT.
Nestle, Frank, MD. Mary Dunhill Chair of Cutaneous Medicine and Immunotherapy, St John's institute of Dermatology, Division of Genetics & Molecular Medicine, King's College London School of Medicine at Guy's, King's & St Thomas’ Hospitals, Floor 8 Guy's Tower, Guy's Hospital, London SE1 9RT.
Newton, Julia, MBBS, MRCP, DipMedSci, PhD, FRCP. Senior Lecturer and Hon. Consultant Physician, Institute of Cellular Medicine, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH.
Paresh, Vyas, BA, BM, DPhil, MRCPath, FRCP, FRCPath. Reader in Haematology, Department of Haematology and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU.
Pritchard, Mark, BSc, MBChB, PhD, FRCP Senior Lecturer and Hon. Consultant Gastroenterologist, Division of Gastroenterology, School of Clinical Sciences, Henry Wellcome Laboratory, Nuffield Building, University of Liverpool, Crown Street, Liverpool L69 3GE.
Randeva, Harpal, MBChB, PhD, FRCP. Senior Lecturer in Medicine, Biomedical Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL.
Reynolds, Nicholas, BSc, MBBS, MD, FRCP. Head of School of Clinical and Laboratory Sciences and Professor of Dermatology, School of Clinical & Laboratory Sciences, Medical School, Newcastle University, Framlington Place, Newcastle-upon- Tyne, NE2 4HH.
Reynolds, Rebecca, MA, MBChB, MRCP, PhD. Senior Lecturer and Hon. Consultant Physician, Endocrinology Unit, Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ.
Strachan, Mark, BSc, MBChB, MD, FRCP. Consultant Physician and Hon. Senior Lecturer, Metabolic Unit, Western General Hospital, Edinburgh EH4 2XU.
Vora, Jiten, BA, MBBChir, MA, MD, FRCP. Consultant Physician and Hon. Senior Lecturer, Department of Diabetes and Endocrinology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP.
Wedzicha, Jadwiga, BA, MBBS, MD, FRCP. Professor of Respiratory Medicine, Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London NW3 2PF.
The new members were welcomed to the Association by the President.
The President then invited the Honorary Treasurer, Professor J.M.C. Connell, to report to the membership.
The Honorary Treasurer, Professor Connell, reported that the accounts of the Association were in good order. He presented income and expenditure for the months to the end of October 2006, but reminded the Committee that the figures were provisional. The Committee was reminded of the strategy to maintain the balance of the accounts to a sum approximately four times the direct charitable expenditure of the Association. The income of the Association had risen, and it was noted that the direct charitable expenditure had risen in an appropriate manner over the next financial year.
Income from subscriptions was stable, and had now been internally audited, so that subscriptions had been reconciled. Income from the Oxford University Press from publication of the Quarterly Journal of Medicine has risen, and the Committee was told that this should rise further in the next financial year as a result of a change in the agreement between the Association and OUP.
Expenditure on management and administration had fallen slightly. The London AGM, as expected, incurred a loss, but this was within the targeted amount. It was expected that the AGM in Bristol would break even.
The present level of expenditure on charitable causes was on target. It had been agreed last year to increase the sum paid to Medical Schools for studentships, and this would be maintained at £1000. The applications for Links with Developing Countries had been of high quality in the last year, and it was agreed that the ceiling for this scheme be maintained at £30 000, to reflect rising costs of travel and accommodation. Finally, it was noted that the number of schools supported in a particular year had increased to eleven, and that the sum made available to support studentships increased to £6000 per annum, so that the expenditure on this scheme was now £66 000 per year.
The members accepted the accounts and the proposals for expenditure.
The President then reported that the Editor of the QJM, Dr Christopher Martyn, had tendered his resignation. The out-going Editor of the QJM, Dr Martyn, had sent his apologies to the meeting. In his absence, Professor Iredale briefly reported on the QJM. Professor Iredale reported that 2006/07 had seen the continuing improvement in the QJM's performance determined by the number of submissions including unsolicited articles received and the number of institutions with access to the journal. In particular, corporate and institutional access consortia represented major purchases of the Journal. The financial state of the Journal was sound and profitability during the last year was greater than expected.
As noted in the previous minutes, a Working Party had been convened to consider strategic issues surrounding the future of the QJM under the chairmanship of Professor Edwin Gale. Professor Gale reported the deliberations of the Working Party. The membership welcomed the report and expressed support for the proposal. The membership then enjoyed a lively discussion of the report and the proposals summarized below.
The Working Party had considered all options for the future of the Journal, including its sale. However, it was decided that the Journal was a valuable asset to the Association, and had the potential to develop and continue to fill an educational role at a time of change in medicine.
The proposed future format for the Journal would fall into three areas: (i) reviews and commentaries; (ii) topical issues concerning the medical community; and (iii) original articles.
It was resolved that Professor Iredale and Professor Kelleher, together with representatives from Oxford University Press, would seek the appointment of a new Editor. It was further proposed that a Steering Group be established to guide and inform the development of the Journal, to support the Editor and to improve liaison between the Association, the Editorial team and the Publishers. The future Editor should be supported by a team of five to six Associate Editors, who would take direct responsibility for soliciting and handling articles within their area of expertise.
Professor Gale led the Association in thanking Dr Martyn for his superb stewardship and editorship of the Journal, and informed the membership that Dr Martyn had been made an Honorary Member of the Association.
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Opening Reception and Annual Dinner |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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The welcome reception on Thursday evening was held in the City Art Gallery. The Annual Dinner was held on the SS Great Britain. Members enjoyed an excellent dinner in superb surroundings and the occasion was enjoyed by all. After dinner, members and guests were addressed by Professor Eric Thomas, Vice Chancellor of the University of Bristol.
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Scientific Business |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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Thursday 29 March 2007
2.00–3.00 pm
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The Osler lecture—Genes, dogma and diabetes |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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Professor Andrew Hattersley, Exeter.
3.00 pm
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(1) Successful gene therapy for Tay-Sachs and related neurodegenerative diseases |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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M.B. Cachon-Gonzalez, S.Z.Wang, R. Ziegler, S.H. Cheng (all introduced), T.M. Cox. Department of Medicine, University of Cambridge, and Genzyme Corporation, Framingham, MA, USA.
We have developed an effective gene therapy for Tay-Sachs and related diseases authentically modelled in mice and cats. Our strategy is now in development for human neurodegenerative diseases.
3.25 pm
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(2) Intestinal dendritic cells selectively induce gut-tropism in T- and B lymphocytes by retinoic-acid-dependent mechanisms |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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B. Eksteen, J.R. Mora, M. Iwata, U.H. Von Andrian (all introduced), D.H. Adams. Institute for Biomedical Research, Wolfson Drive, University of Birmingham, Birmingham.
Dendritic cells in gut-associated lymphoid tissue induce gut specificity in T and B lymphocytes by retinoic acid, which leads to selective lymphocyte homing to the gut and IgA production.
4.15 pm
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(3) Remote ischaemic preconditioning in humans |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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S.P. Loukogeorgakis, L. Rees, R.N. Dalton (all introduced) J.E. Deanfield, R.J. MacAllister. Institute of Child Health, University College London.
Remote ischaemic preconditioning (RIPC) is a potent innate protective mechanism against ischaemia reperfusion (IR) injury. RIPC can be induced by transient limb ischaemia in animals and humans and has salutary effects against experimental and clinical IR.
4.40 pm
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(4) Insights from a humanized mouse model of psoriasis define a novel epithelial homing effector T cell population |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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F.O. Nestle, G. Tonel, U. Laggner, O. Boyman, A De Fougerolles, V. Kotelianski, H. Gardener, C. Conrad (all introduced by R Lechler). St John's Institute of Dermatology, King's College London School of Medicine, Guy's Hospital, London.
Epithelial effector T cells in common cutaneous inflammation.
5.05 pm
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(5) Benefits and risks of anti-TNF therapy in patients with rheumatoid arthritis |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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W.G. Dixon, K. Watson, M. Lunt, K. Hyrich (all introduced), D.P.M. Symmons. ARC Epidemiology Unit, Stopford Building, Oxford Road, Manchester.
Anti-TNF therapy in patients with drug-resistant rheumatoid arthritis leads to improved disease activity, a reduced rate of MI and possibly lymphoma but increased intracellular bacterial infections.
Friday 30 March 2007
9.00 am
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(6) Targeted molecular therapy for inherited glycosylphosphatidylinositol deficiency |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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D.M. Layton, A.M. Almeida, Y. Murakami, A. Baker, Y. Maeda, I.A.G. Roberts, T. Kinoshita, A. Karadimitris (all introduced by P.H. Maxwell). Department of Haematology, Imperial College, Hammersmith Hospital, London.
Correction of inherited defect in glycosylphosphatidylinositol biosynthesis in vitro and in vivo by butyrate.
9.25 am
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(7) Dendritic cell stimulation by mycobacterial HSP70 is mediated through the HIV co-receptor CCR5 |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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R.A. Floto, P.A. Macary, J.M. Boname, B. Kampmann, J. Pieters, C. Day, W. Oehlmann, M. Singh (all introduced), K.G. Smith, P. J. Lehner. Department of Medicine, CIMR, Addenbrooke's Hospital, Cambridge.
We have shown that the HIV co-receptor CCR5 acts as a pattern recognition receptor for a mycobacterial heat shock protein myHSP70 and triggers dendritic cell stimulation.
9.50 am
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(8) Novel SNPs in the regulatory region of the 11ß-hydroxylase gene in man (CYP11B1) associated with reduced transcriptional activity in vitro and resetting of the pituitary-adrenal axis in hypertension |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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E.M. Freel (introduced), M. Barr, R. Fraser, E. Davies, J.M.C. Connell. Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow.
Aldosterone is important in hypertension and cardiovascular disease. These data provide insights into novel molecular and biochemical mechanisms of hypertension with aldosterone excess.
10.15 am
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(9) Mechanism of haemolytic uraemic syndrome associated with hereditary factor H deficiency |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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M.C. Pickering, E. Goicoechea De Jorge, K.L. Rose, J. Moss (all introduced), M.J. Walport, H.T. Cook (introduced), S. Rodriguez De Cordona (introduced), M. Botto. Molecular Genetics & Rheumatology Section, Imperial College, Hammersmith Hospital, London.
This study describes the first animal model of atypical haemolytic syndrome. It also provides in vivo evidence that different functional alterations in complement factor H result in distinct renal pathology.
11.10 am
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(10) Identification of GLI-1 as an IBD2 susceptibility gene |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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C.W. Lees, E. Nimmo, A. Tenesa, H. Campbell, S.E.M. Howie, M.G. Dunlop (all introduced), J. Satsangi. Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh.
A gene-wide haplotype-tagging study has demonstrated a strong association between inherited variation in GLI-1, the major Hedgehog pathway effector and UC susceptibility, providing evidence that GLI-1 is the IBD2 gene.
11.35 am
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(11) The molecular mechanism for reversing corticosteroid resistance in COPD by theophylline |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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K. Ito, Y. To, I.M. Adcock (all introduced), P.J. Barnes. National Heart and Lung Institute, Imperial College, London.
Low dose theophylline is reverses corticosteroid resistance in COPD cells via restoration of histone deacetylase-2 activity though inhibition of phosphatidylinositol-3 kinase-
, which is activated by oxidative stress and responsible for the decrease in HDAC2 activation in COPD.
12 noon
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(12) Myeloid preleukaemia and leukaemia in children with Down Syndrome |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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P. Vyas, A. Norton, I. Roberts (all introduced by D.R. Higgs). Department of Haematology & Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.
Children with Down Syndrome are predisposed to acute myeloid leukaemia. We report that trisomy 21 and mutations in the transcription factor GATA1 are distinct synergistic events in fetal blood cell transformation.
12.25 pm
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(13) Effective T-cell responses select HIV-1 mutants and slow disease progression |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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A.J. Frater, A. Oxenius, H. Gunthard, P. Goulder, A. Mclean (all introduced), R.E. Phillips. Peter Medawar Building for Pathogen Research, South Parks Road, Oxford.
The advantage conferred by some HLA Class 1 molecules in HIV infection can be attributed to the imposition of strong selection pressures and the replicative cost to the virus of immune escape.
3.00 pm
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(14) Modulation of adaptive immune responses to HIV-1 by therapeutic vaccination |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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L. Dorrell, H. Yang, T. Dong, B. Ondondo, A. Guimaraes-Walker, S. Ranasinge, K. Di Gleria, S. Howles, P. Bowness, N. Goonetilleke (all introduced by A. McMichael), C. Conlon, T. Hanke (introduced), A. Mcmichael. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University.
HIV-1-specific cell-mediated immunity can be improved by immunization during antiretroviral therapy with a recombinant poxvirus-vectored vaccine. Failure of adaptive CD8+ T cell responses to contain HIV-1 may be due partly to their slow expansion rate relative to the rate of HIV-1 replication.
3.25 pm
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(15) Inflammation and ion transport in cystic fibrosis—finding the missing link |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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Mehta, (introducing the following) K.J. Treharne, R.M. Crawford, D.N. Sheppard, K. Kunzelmann, L.A. Pinna. Department of Maternal & Child Health Sciences, University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY on behalf of 1Bristol and 2Regensburg and 3Padua University authors.
We link for the first time inflammation and ion transport in cystic fibrosis into a single model induced by dysfunction of sub-cellular localization of a protein kinase with many hundreds of targets in cell signalling.
3.50 pm
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(16) Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6Q23 influencing HBF levels in adults |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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S.L. Thein1, S. Menzel1, X. Peng2, S. Best1, J. Jiang1, J. Close1,3, N. Silver1, A. Gerovassili1, C. Ping2, M. Yamaguchi2, K. Wahlberg1, H. Muller1, T.D. Spector4, C. Garner5, F. Matsuda2, M. Farrell6, M. Lathrop2 (all introduced by S.L. Thein). 1King's College London (KCL) School of Medicine at King's College Hospital, London, 2CNG, 91006 Evry, France, 3SANE POWIC, University of Oxford, 4KCL School of Medicine at St Thomas’ Hospital, London, 5Department of Medicine, University of California, USA, 6WTCHG, University of Oxford.
Identification of sequence variants outside of the globin gene locus suggests novel pathways of fetal haemoglobin control in adults and strategies for potential therapeutic targets.
4.45 pm
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(17) Genome-wide cell-specific expression analysis identified the involvement of the adipocytokine signalling pathway in atherosclerotic plaque rupture |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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K. Lee, T. Polvikoski, D. Birchall, M. Santibanez-Koref, A. D. Mendelow (all introduced), B. Keavney. Institute of Human Genetics, University of Newcastle upon Tyne, NE1 3BZ.
Cell-specific laser microdissection and genome-wide expression analysis in macrophages from stable and unstable atheromatous plaques.
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History of Medicine Lecture—Mind Parasites and Disease |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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Professor Edwin Gale
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Demonstrations |
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TopExecutive CommitteeOrdinary MembersOpening Reception and Annual...Scientific BusinessThe Osler lecture--Genes, dogma...(1) Successful gene therapy...(2) Intestinal dendritic cells...(3) Remote ischaemic...(4) Insights from a...(5) Benefits and risks...(6) Targeted molecular therapy...(7) Dendritic cell stimulation...(8) Novel SNPs in...(9) Mechanism of haemolytic...(10) Identification of GLI-1...(11) The molecular mechanism...(12) Myeloid preleukaemia and...(13) Effective T-cell responses...(14) Modulation of adaptive...(15) Inflammation and ion...(16) Intergenic variants of...(17) Genome-wide cell-specific...History of Medicine Lecture-...Demonstrations |
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1. Human podocytes—an essential tool in unravelling the mechanism of nephrotic syndromes. M Saleem, P Mathieson, N Lan, R Foster, R Coward, G Welsh, R Lennon. Academic Renal Unit, University of Bristol.
2. The cellular basis for the anti-proteinuric actions of interferon beta. SC Satchell, CH Tasman, MA Saleem, PW Mathieson. Academic Renal Unit, University of Bristol.
3. Nephrin is critical for the action of insulin on human glomerular podocytes. RJM Coward, GI Welsh, A. Koziell, S Hussain, R Lennon, L Ni, JM Tavaré, PW Mathieson, MA Saleem. Academic Renal Unit, University of Bristol.
4. Sniffing out the cause of diarrhoea: volatile organic compounds from faeces and their potential for gastrointestinal disease diagnosis. CE Garner, S Smith, B de Lacy Costello, P White, R Spencer, NM Ratcliffe, CSJ Probert. Department of Clinical Science at South Bristol, University of Bristol.
5. Vascular progenitor cells from human arteries and veins. P Campagnolo, G Angelini, P Madeddu. Bristol Heart Institute, University of Bristol.
6. NGF Promotes Cardiomyocyte Survival via IP3-K, Akt and Foxo. A Caporali, GB Sala-Newby, C Emanueli. Bristol Heart Institute, University of Bristol.
7. Folic acid reduces intravascular oxidative stress in Diabetic rabbits. N Shukla, GD Angelini, JY Jeremy. Bristol Heart Institute, University of Bristol.
8. Hydrogen sulphide is a potent inhibitor of NADPH oxidase activity and expression in vascular smooth muscles. S Muzaffar, N Shukla, JY Jeremy. Bristol Heart Institute, University of Bristol.
9. Superoxide from NADPH oxidase upregulates the expression of type 5 phosphodiesterase in vascular smooth muscle cells. S Muzaffar, N Shukla, JY Jeremy. Bristol Heart Institute, University of Bristol.
10. The role played by Galanin and GALR2 in the modulation of neuropathic pain, neuronal survival and regeneration. D Wynick. Departments of Pharmacology and Clinical Sciences at South Bristol, University of Bristol.
11. A Single Population of Cells in the Male Rat Anterior Pituitary Responds Mitotically to Both Gonadectomy and Adrenalectomy. LA Nolan, A Levy. Henry Wellcome Laboratories, University of Bristol.
12. Transient Uncoupling of Mitotic and Apoptotic Co-regulation in the Normal Male Rat Pituitary: a Potential Model of Pituitary Microadenoma Formation. A Levy, LA Nolan. Henry Wellcome Laboratories, University of Bristol.
13. Predicting type 1 diabetes: Experience from a multinational intervention trial. KM Gillespie, AJK Williams, EAM Gale, PJ Bingley. Diabetes and Metabolism Unit, University of Bristol.
14. Maternal microchimerism in type 1 diabetes: friend or foe? KM Gillespie, JL Nelson, NC Lambert, AM Stevens, LS Loubière, JC Rutledge, WM Leisenring, TD Erickson, Z Yan, ME Mullarkey, ND Boespflug, PJ Bingley, EAM Gale. Diabetes and Metabolism Unit, University of Bristol.
15. Proinflammatory and regulatory T cell responses in newly-diagnosed Type 1 diabetes, healthy controls and first-degree relatives. L Connor, J Fu, L Marquesini, C Baker, A Bishop, S Wong. C Dayan. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol.
16. Psychological well-being and thyroid function: results from analysis of 3 large cohorts. V Panicker, M Williams, J Evans, Y Ben-Shlomo, P Saravanan, C Dayan. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol.
17. The role of endogenous stem cells in spontaneous repair in multiple sclerosis. H Snethen, S Love, NJ Scolding. MS and Stem Cell Research, University of Bristol.
18. Microglial activation, reduced labelling of astrocytes and loss of perineuronal nets in cerebral cortex in multiple sclerosis. T Thomas, E Gray, N J Scolding, S Betmouni, S Love. MS and Stem Cell Research, University of Bristol.
19. In vitro model of the perineuronal net. S Baig, E Gray, N J Scolding, S Betmouni, S Love. Institute of Clinical Neurosciences, University of Bristol.
20. ACE levels and activity in Alzheimer's disease, and relationship to cerebral amyloid angiopathy. S Miners, Z Van Helmond, K Chalmers, L Palmer, S Love, P Kehoe. Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol.
21. Reduced neprilysin expression in Alzheimer's disease is associated with APOE e4 and cerebral amyloid angiopathy. S Miners, Z Van Helmond, K Chalmers, S Love, G Wilcock, P G Kehoe. Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol.
22. Rapid shuttling of activated glucocorticoid receptors into and out of the nucleus. The importance of the intranuclear proteasome. BL Conway-Campbell, MA McKenna, CC Wiles, HC Atkinson, L Harrison, SA Wood, SL Lightman. University of Bristol.
23. Evidence for a population of brainstem serotonin neurones that respond to inflammation and regulate mood. CA Lowry, JH Hollis, A de Vries, B Pan, LR Brunet, JRF Hunt, JFR Paton, E van Kampen, DM Knight, AK Evans, GAW Rook, SL Lightman. University of Bristol.
24. Rapid non-genomic effects of corticosteroids. Evidence for the importance of mineralocorticoid receptors. HC Atkinson, SA Wood, YM Kershaw, SL Lightman. Laboratories for integrative Neuroscience and Endocrinology, University of Bristol.
25. Development of an Automated Blood Sampling System for use in Humans. D Henley, G Russell, J Leendertz, S Taheri, S Lightman. Henry Wellcome Laboratories, University of Bristol.
26. Factors Associated with Sleep Duration in Infants – Data from the Avon Longitudinal Study of Parents and Children (ALSPAC). S Taheri, P Fleming, P Blair, J Henderson, S Leary, AR Ness, J Golding. ALSPAC study team, University of Bristol.
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