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QJM 2005 98(8):615-620; doi:10.1093/qjmed/hci099
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© The Author 2005. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Correspondence

Molecular detection of Coxiella burnetii in blood and sera during Q fever

J.-M. Rolain and D. Raoult

Unité des Rickettsies Faculté de Médecine Université de la Méditerranée Marseille France email: didier.raoult@medecine.univ-mrs.fr

The first 150 words of the full text of this article appear below.

Sir,

We read with interest the intriguing article by Marmion et al.1 which describes the molecular detection of Coxiella burnetii in two cohorts of patients from Australia and the UK, 5 years and 12 years after initial infection, respectively. Their data suggest that C. burnetii DNA may persist up to 12 years in blood of patients who are eventually cured, or those suffering only from fatigue. Moreover, authors found that PCR targeting single-copy genes such as Com1 and 16S rRNA genes, wase more sensitive than that targeting the 1S1111a repetitive element.2 According to these authors, PCR targeting 1S1111a was negative in the UK cohort, presumably due to the absence of these insertion elements in the strain of C. burnetii that was the causative agent of Q fever in this patient population.

In our opinion, such a notion is conjecture, since C. burnetii was not isolated from any of the . . . [Full Text of this Article]

B.P. Marmion, R.J. Harris and P. Storm

Q Fever Research Group Adelaide Australia

J.G. Ayres

Department of Environmental and Occupational Medicine University of Aberdeen Aberdeen UK


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