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QJM 2005 98(12):916-918; doi:10.1093/qjmed/hci144
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© The Author 2005. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Correspondence

Bone crisis in stable Gaucher's disease

The first 10% of the full text of this article appears below.

Sir,

During the past 20 years, modern treatments have dramatically changed the prognosis for symptomatic patients with type 1 Gaucher's disease (GD). Since 1991, therapy has shifted from an approach primarily directed at symptom control to the actual reduction of glucocerebroside cellular burden. The latter therapeutic option has been realized through enzyme replacement therapy (ERT) and, more recently, with the use of miglustat, an oral substrate synthesis inhibitor (an . . . [Full Text of this Article]

J.I. Pérez-Calvo and M. Roca-Espiaú

Hospital Clínico Universitario Zaragoza Spain

G.M. Pastores

Neurogenetics Program New York University School of Medicine New York USA

email: mibh-jperezcu@lblesa.es


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