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Q J Med 2003; 96: 319-320
© 2003 Association of Physicians

Biologic

Models have real value

Colin Berry

The first 10% of the full text of this article appears below.

Those of you who have kept tropical fish will almost certainly have had the Zebrafish (Daneo rerio) in your menagerie. You may not know that this fish is now perhaps the most important tool in the investigation of normal development and in the identification of candidate genes that play a determining role in human malformation syndromes.

A deliberate programme of chemical mutagenesis has identified hundreds of mutations that affect vertebrate development affecting the form of the embryo, the generation of the germ layers, organogenesis, differentiation, the cytoarchetectonics of the brain and . . . [Full Text of this Article]


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