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Q J Med 2002; 95: 423-429
© 2002 Association of Physicians

Review

Is exercise blood pressure a marker of vascular endothelial function?

N. Tzemos, P.O. Lim and T.M. MacDonald

From the Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, and 1 Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK

The first 150 words of the full text of this article appear below.


   Introduction
 
Blood pressure (BP) during exercise is routinely measured during treadmill testing of individuals with chest pain. An abnormal response, whereby the BP falls or fails to rise during exercise, is universally accepted to be a sign of more severe cardiac ischaemia. Similarly, such responses in patients with hypertrophic cardiomyopathy indicate a high risk for cardiac death, hence exercise BP assessment is now included in the routine work-up of these patients. The converse, i.e. an exaggerated BP response (ExBPR) during exercise is more controversial, especially when seen in apparently healthy individuals. There are, however, accumulating data to suggest that ExBPR is an early sign of cardiovascular disease. In particular, ExBPR seems to relate to the future development of hypertension, left ventricular hypertrophy (LVH) and is also a potent predictor of future cardiac events. The origin of ExBPR is incompletely understood at present. In this brief review we examine the available literature . . . [Full Text of this Article]


   The prognostic value of exercise BP response
 

   A brief physiology of exercise BP
 

   Normal exercise physiology and NO
 

   Indirect evidence of NO involvement during exercise
 

   Link between abnormal exercise BP response and NO bioactivity
 

   Conclusions
 

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Home page
 Cleveland Clinic Journal of MedicineHome page
M. S. LAUER and T. D. MILLER
The exercise treadmill test: Estimating cardiovascular prognosis
Cleveland Clinic Journal of Medicine, June 1, 2008; 75(6): 424 - 430.
[Abstract] [Full Text] [PDF]