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Q J Med 2002; 95: 415-416
© 2002 Association of Physicians

Biologic

Ahead of the head

Colin Berry

In a previous article in this series,1 I discussed the problems of pattern formation in the central nervous system (CNS) and left the forebrain out; it is different, complicated, poorly understood and thus easy to speculate about. With the recent controversy concerning the treatment of a child with a severe abnormality of the face, head and neck, it now seems appropriate to tackle part of this problem. How do such anomalies develop, and what have apparently mesodermal (even neuromesodermal) defects to do with the brain?

The pattern-determining mechanisms operating in the rest of the CNS do not include . . . [Full Text of this Article]

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