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Q J Med 2002; 95: 259-260
© 2002 Association of Physicians

Biologic

Variety

Colin Berry

Until comparatively recently, genomes were thought to change slowly and by a limited number of mechanisms (single base pair mutations, chromosome rearrangements and sequence duplication). In mammals, the major factor in speciation appears to be duplication of parts of the genome, and although most of this type of change was thought to have occurred more than 450 million years ago, the sequencing of a number of genomes has recently made this assumption untenable.1

Around 5% of our genome is composed of segmental duplications that have . . . [Full Text of this Article]

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