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Q J Med 2002; 95: 765-766
© 2002 Association of Physicians

Biologic

Keeping it together

Colin Berry

The first 10% of the full text of this article appears below.

It is clearly necessary for land based mammals to have a skin. The epithelial permeability barrier (EPB) prevents dehydration, the ingress of micro-organisms and toxins, and permits some forms of selective absorption. The skin also has an important role in temperature regulation. But there are some surprises in how we get it.

By 4 weeks gestational age in Man, the ectoderm has given rise to a basal layer of keratinocytes covered by a layer of periderm cells. By 9–10 weeks, progressive stratification becomes evident and the main components of the skin then begin to develop. The epidermis forms a proliferative compartment, from which cells become irreversibly committed to terminal development. . . . [Full Text of this Article]


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