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Q J Med 2002; 95: 709-710
© 2002 Association of Physicians

Biologic

Minnie mice

Colin Berry

The first 10% of the full text of this article appears below.

In determining the size of an animal or plant, it has long been thought that size itself is in some way measured and monitored. Experimental manipulation of rates of cell proliferation or cell size during growth results in organs and/or organisms of the normal size that may consist of fewer larger cells, or more numerous smaller cells.1 As Day and Lawrence2 have pointed out, when looking for answers to questions about how this is achieved, the intuitive response is to search for mechanisms that count cell divisions or add up cell numbers.

Ploidy is clearly . . . [Full Text of this Article]


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