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Q J Med 2001; 94: 504-506
© 2001 Association of Physicians

Correspondence

Antiphospholipid syndrome presenting as cardiac failure

V. Adhiyaman, R. Donepudi, F. Douglas and M.J. Kumwenda

Department of General/Renal Medicine, Glan Clwyd District General Hospital, Rhyl

Sir,

Antiphospholipid syndrome (APS) is a thrombophilic disorder commonly associated with venous and arterial thrombosis, recurrent fetal loss and thrombocytopenia. Even though cardiac manifestations are well recognized, congestive cardiac failure (CCF) as an initial presenting feature is very uncommon. We present three cases presenting predominantly as cardiac failure where the diagnosis of APS emerged later.

Patient 1, a 67-year-old woman, presented with increasing dyspnoea and uncontrolled hypertension of a few weeks duration. Past medical history included dermatomyositis, mastectomy for carcinoma of the breast and a left total hip replacement. There was no previous history of hypertension. Her drug therapy comprised of prednisolone 5 mg a day, ranitidine and prothiaden. On examination she was hypertensive . . . [Full Text of this Article]

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