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Q J Med 2000; 93: 559-560
© 2000 Association of Physicians

Correspondence

Thymoma, autoimmunity and fatal immunodeficiency

C.A. McCune, S. Hughes and D.J. Unsworth

Department of Medicine, Frenchay Hospital, Bristol Department of Medicine Department of Immunology, Southmead Hospital, Bristol

Sir,

A 47-year-old male presented to us in 1995 with diarrhoea, weight loss, lichen planus, oesophageal candidiasis and streptococcal pneumonia. HIV serology and PCR tests were negative. Lymphocyte subset analysis confirmed normal T-cell numbers, but absence of CD 19+ B lymphocytes. Severe pan-hypogammaglobulinaemia was confirmed (IgG, IgA, IgM 1.6 g/l, 0.2 g/l, and 0.15 g/l, respectively). The differential diagnosis included haematological malignancy, and primary immunodeficiency. . . . [Full Text of this Article]

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