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Q J Med 2000; 93: 198-201
© 2000 Association of Physicians


Correspondence

Recurrent and prolonged fever in asplenic patients with human granulocytic ehrlichiosis

A. RABINSTEIN, V. TIKHOMIROV, A. KALUTA, N. GELFMANN, P. IANNINI and L. EDWARDS

Department of Medicine Department of Pathology, Danbury Hospital, Yale University School of Medicine, Danbury CT, USA

Sir,

The ehrlichioses are emerging zoonotic infections transmitted by ticks and caused by obligate intracellular organisms of the genus Ehrlichia. Two forms of human infection have been distinguished: human monocytic ehrlichiosis (HME), caused by E. chaffeensis1 and human granulocytic ehrlichiosis (HGE), caused by an organism shown to be phylogenetically similar to E. equi and E. phagocytophilia.2 The first report of human ehrlichiosis in the US was published in 1987.3 These increasingly recognized infections present a difficult diagnostic challenge as a result of their protean clinical manifestations and the absence of a reliable laboratory marker, especially in the acute stage of the disease.

Although HGE is most commonly considered in cases of brief, acute febrile illness, it can take an unusual clinical course, especially in cases of coinfection with other parasites, such as Babesia or Borrelia. The disease can also take a different course . . . [Full Text of this Article]

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