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Q J Med 1999; 92: 361-364
© 1999 Association of Physicians

Editorial

Helicobacter pylori in the faeces?

L.T. Weaver, A.J. Shepherd and C.P. Doherty

Department of Child Health

K.E.L. McColl

Department of Medicine & Therapeutics, University of Glasgow

C.L. Williams

Department of Microbiology, Royal Alexandra Hospital, Paisley

The most surprising thing about Helicobacter pylori is its site of residence—within the stomach. Failure of early reports of the presence of spiral gastric organisms1 to evoke much interest was probably due to a general reluctance to view the stomach as a habitat for micro-organisms because of the extreme acidity of its lumen. Marshall and Warren's `discovery' in 19822 changed that, and now, within 18 years of the cultivation of a microaerophilic flagellated spiral organism from the human stomach, H. pylori is not only regarded as the commonest chronic bacterial infection of mankind,3 but also the principal cause of duodenal ulcer disease4 and an important factor in the pathogenesis of gastric cancer.5

The ability of H. pylori to survive and thrive in the stomach is due to several factors. The organism is motile and can penetrate the gastric mucus to reach the epithelial surface. It also secretes urease, which hydrolyses . . . [Full Text of this Article]

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Home page
 Arch. Dis. Child.Home page
A. J Shepherd, C. L Williams, C. P Doherty, M. Hossack, T. Preston, K. E L McColl, and L. T Weaver
Comparison of an enzyme immunoassay for the detection of Helicobacter pylori antigens in the faeces with the urea breath test
Arch. Dis. Child., September 1, 2000; 83(3): 268 - 270.
[Abstract] [Full Text] [PDF]