QJM Advance Access originally published online on February 12, 2008
QJM 2008 101(4):329-330; doi:10.1093/qjmed/hcn010
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© The Author 2008. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Humoral hypercalcaemia of benignancy. A case report
Diabetes Unit, St Richards Hospital
Spitalfield Lane, Chichester
PO19 6SE, UK
email: roselle.herring1@btinternet.com
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Sir,
Humoral hypercalcaemia of benignancy is characterized by a benign tumour producing hypercalcaemia induced by parathyroid hormone related protein (PTHrP). This condition is rare. Five previous cases have been reported in English, an ovarian dermoid cysts, mammary hyperplasia1 two cases related with uterine leiomyoma,2 and one with phaeochromocytoma.3 A possible association with an intestinal leiomyomyoma has also been reported. We present a case of PTHrP secreting benign uterine leiomyoma. Association was confirmed by normalization of calcium levels after tumour resection.
Hypercalcaemia associated with malignancy