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QJM Advance Access originally published online on December 26, 2007
QJM 2008 101(2):161-163; doi:10.1093/qjmed/hcm129
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© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Subjects expressing the glucose-6-phosphate dehydrogenase deficient phenotype experience a lower cardiovascular mortality

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Sir,

In a recent mortality follow-up study of lead smelters in southwestern Sardinia, Italy, whose glucose-6-phosphate dehydrogenase (G6PD) phenotype was part of the pre-employment screening program, workers expressing the G6PD deficient (G6PD–) phenotype showed a substantial reduction in cardiovascular mortality.1 The same result was previously reported in a follow-up study of G6PD– subjects who voluntarily participated in a population screening,2 as well as in a US cross-sectional study of hospitalized patients.3 Interpretation of those earlier findings was limited by possible . . . [Full Text of this Article]

P. Cocco and D. Fadda

Department of Public Health
Occupational Health Section
University of Cagliari
Italy
email: coccop@pacs.unica.it

A.G. Schwartz

FELS Institute
Temple University School of Medicine
Philadelphia
USA


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