QJM Advance Access originally published online on August 24, 2008
QJM 2008 101(10):827-828; doi:10.1093/qjmed/hcn104
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Effect of serum albumin on serum sodium: necessity to consider the Donnan effect
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Sir,
In a recent issue of QJM, Kengne et al. defined the association between mild asymptomatic hyponatremia and bone fracture.1 However, the defined association might reflect the effect of hypoalbuminemia on bone fracture and incidental fall, because hyponatremia frequently associates with hypoalbuminemia and the
Appendix 1
Division of Nephrology, Hypertension &
Endocrinology
Department of Medicine
Tohoku University Graduate School of Medicine
Sendai, Miyagi
Japan
email: mtanemoto-tky@umin.ac.jp