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QJM Advance Access published online on November 5, 2009
QJM, doi:10.1093/qjmed/hcp159
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© The Author 2009. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Apical potassium (BK) channels and enhanced potassium secretion in human colon

G. I. Sandle1 and M. Hunter2

From the 1Institute of Molecular Medicine, St James’s University Hospital, Leeds LS9 7TF and 2Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK

Address correspondence to Prof. G.I. Sandle, Institute of Molecular Medicine, St James’s University Hospital, Leeds LS9 7TF, UK. email: g.i.sandle{at}leeds.ac.uk


  Abstract

The human colon has the capacity to secrete potassium (K+) ions and enhanced K+ secretion is a feature of a variety of diarrhoeal diseases. Recent work points to K+ secretion in human colon being mediated by high conductance (BK) K+ channels located in the apical membrane of colonic epithelial cells. The aim of this review is to highlight the importance of these channels in maintaining K+ homoeostasis in health and disease.


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