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QJM Advance Access published online on October 14, 2009
QJM, doi:10.1093/qjmed/hcp146
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© The Author 2009. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Acute renal failure from nitrofurantoin-induced acute granulomatous interstitial nephritis

G. Namagondlu1, S.E. Low2, R. Seneviratne2 and A. Banerjee1

From the 1Department of Nephrology and 2Department of Pathology, Wirral University Hospital NHS Foundation Trust, Arrowe Park Road, Wirral CH49 5PE, UK

Address correspondence to A. Banerjee, Department of Nephrology, Wirral University Hospital NHS Foundation Trust, Arrowe Park Road, Wirral CH49 5PE, UK. email: anindya.banerjee{at}coch.nhs.uk


  Abstract

We report here a case of acute renal failure with nitrofurantoin-associated acute granulomatous interstitial nephritis (GIN), which was commenced as a long-term prophylactic agent for suspected recurrent urinary tract infections. Renal function improved with withdrawal of this agent and without the requirement of corticosteroids. All new medication changes should be held in suspicion as a cause of acute onset abnormalities in serum biochemistry.


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