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QJM Advance Access originally published online on May 6, 2009
QJM 2009 102(8):569-573; doi:10.1093/qjmed/hcp053
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© The Author 2009. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Thomas Addison's disease after 154 years: modern diagnostic perspectives on an old condition

L. Leelarathna, J.K. Powrie and P.V. Carroll

From the Department of Endocrinology, Guy's and St Thomas’ NHS Foundation Trust London, UK

Address correspondence to L. Leelarathna, Department of Endocrinology, Guy's Hospital, London SE1 9RT, UK. email: lalantha.leelarathna{at}gstt.nhs.uk


   Abstract

Thomas Addison was first to describe adrenocortical failure in 1855. Despite advances in the treatment of this condition, the diagnosis is still often delayed and sometimes missed with potentially fatal consequences. From the same institution where Thomas Addison performed his original autopsy studies, we present four recent cases highlighting the wide clinical spectrum and discuss how modern biochemical and immunological tests could be utilized in early diagnosis and aetiological classification.


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