Skip Navigation

QJM 2004 97(9):599-607; doi:10.1093/qjmed/hch094
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Akashi, Y.J.
Right arrow Articles by Miyake, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akashi, Y.J.
Right arrow Articles by Miyake, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

QJM vol. 97 no. 9 © Association of Physicians 2004; all rights reserved.

Plasma brain natriuretic peptide in takotsubo cardiomyopathy

Y.J. Akashi1,2, H. Musha1, K. Nakazawa2 and F. Miyake2

From the 1Department of Cardiology, St Marianna University, Yokohama-city Seibu Hospital, Yokohama, and 2Division of Cardiology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan

Received 23 December 2003 and in revised form 31 March 2004

Background: Takotsubo cardiomyopathy is a reversible left ventricular dysfunction with symptoms resembling acute myocardial infarction, but without coronary lesions. Patients have wall motion abnormalities (apical akinesis and basal hyperkinesis), and characteristic left ventricular morphology.

Aim: To investigate plasma brain natriuretic peptide (BNP) concentrations in takotsubo cardiomyopathy.

Methods: Ten consecutive patients with takotsubo cardiomyopathy underwent cardiac catheterization on their first hospital day, and blood was collected to measure BNP. To evaluate acute basal hyperkinesis, the difference in diameter between systole and diastole was measured at 10 mm below the aortic valve (the {delta}Base value).

Results: Coronary angiography revealed no significant stenosis in any patient. Initial ejection fraction was 42.2 ± 7.3%, cardiac index was 1.90 ± 0.39 l/min/m2, and plasma BNP was 522.5 ± 632.9 pg/ml. Ventricular contraction and the ejection fraction were normalized on echocardiography after 17.9 ± 6.3 days. BNP was significantly correlated with {delta}Base, but not with other cardiac parameters.

Discussion: Initial {delta}Base value seems to be a good indicator of the severity of basal hyperkinesis in patients with takotsubo cardiomyopathy. In contrast to other diagnoses, a high BNP concentration is not associated with a poor prognosis in this condition.

Address correspondence to Dr Y.J. Akashi, Division of Cardiology, Dept. of Internal Medicine, St Marianna University School of Medicine, 2–16–1 Sugao Miyamae-ku, Kawasaki-city, Kanagawa-pref., 216-8511, Japan. e-mail: johnny{at}marianna-u.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Crit Care NurseHome page
B. McCulloch
Transient Left Ventricular Apical Ballooning
Crit. Care Nurse, December 1, 2007; 27(6): 20 - 27.
[Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
R. Iengo, G. Marrazzo, S. Rumolo, M. Accadia, M. Di Donato, L. Ascione, and B. Tuccillo
An unusual presentation of "tako-tsubo cardiomyopathy"
Eur J Echocardiogr, December 1, 2007; 8(6): 491 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Gianni, F. Dentali, A. M. Grandi, G. Sumner, R. Hiralal, and E. Lonn
Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review
Eur. Heart J., July 1, 2006; 27(13): 1523 - 1529.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.