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Q J Med 2004; 97: 451-455
QJM vol. 97 no. 7 © Association of Physicians 2004; all rights reserved.

Commentary

The prevention of type 2 diabetes mellitus: recent advances

N. Younis1, H. Soran2 and S. Farook1

From 1Department of Diabetes & Endocrinology, University Hospital Aintree, Liverpool, and 2Department of Diabetes & Endocrinology, Stepping Hill Hospital, Stockport, UK

Diabetes is a major public health problem that is approaching epidemic proportions globally. There is an urgent need for strategies to curb the rising prevalence of this disease, and prevention appears a logical approach. Lifestyle modifications with weight loss and moderate exercise can reduce the incidence of diabetes by >50% in patients with impaired glucose tolerance (IGT). The use of metformin, acarbose and other agents have been shown in randomized prospective trials to prevent type 2 diabetes in high-risk subjects with IGT. Other pharmacological interventions are currently being examined in large prospective studies. It is likely that one or a combination of these approaches could make diabetes prevention a reality in the near future.

Address correspondence to Dr N. Younis, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT. e-mail: naveedy{at}tinyonline.co.uk


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